İlayda Üzümcü1, Oytun Erbaş2

1Institute of Experimental Medicine, Gebze-Kocaeli, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey

Keywords: Bone marrow transplantation, cancer, solid tumors, stem cell

Abstract

Bone marrow transplantation (BMT) has been applied in the treatment of solid tumors such as breast cancer, brain tumor, multiple myeloma, testis/ germ cell tumor, neuroblastoma, and lymphoma. High dose chemotherapy, radiation therapy, and preparative regimen is also used with BMT to improve disease-free survival, morbidity, mortality, remission, complications, relapse, and response to treatment. Post-transplant infection, toxicity, graft-versus-host disease, recurrence, and secondary malignant tumors can occur. Therefore, the patient should be monitored for an extended dura- tion, and intensive medical care should be applied to the patient. The treatment methods used during the transplant are constantly adapted to pre- vent these side effects. The success of the transplant depends on the transplant type, patient age, and disease status. Bone marrow transplantation is becoming increasingly common since its efficacy has been proven in many diseases and has curative/mitigating potential. This review aimed to define BMT and solid tumors and discuss related studies.