Superparamagnetic iron oxide nanoparticles use in the temporal lobe epilepsy model
Özge Çağlar1,2, Elif Özyılmaz3, Oytun Erbaş2,4
1Department of Chemistry, Selçuk University, Faculty of Science, Konya, Turkey
2Institute of Experimental Medicine, Gebze-Kocaeli, Turkey
3Department of Biochemistry, Selçuk University, Faculty of Science, Konya, Turkey
4Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey
Keywords: Epilepsy, magnetic nanoparticles, superparamagnetic iron oxide nanoparticles, temporal lobe epilepsy
Epilepsy is one of the oldest and most important diseases in the world, affecting the lives of many people. Although the basis of its treatment is anti-seizure drugs, only 70% of patients respond to drug therapy. Temporal lobe epilepsy (TLE), which means drug-resistant epilepsy, is the most common condition of focal epilepsy. In the case of TLE, new methods are needed, considering the possible situations that may occur during surgical intervention. In recent years, it is thought that superparamagnetic iron oxide nanoparticles, which have attracted attention with their wide range of use, biocompatibility, and unique properties, may contribute to magnetic targeted drug therapy. This review aimed to evaluate the effect of superparamagnetic iron oxide nanoparticles on TLE.