Ömer Demir1, Oytun Erbaş2

1Istanbul Medeniyet University, Faculty of Engineering and Natural Sciences, Istanbul, Türkiye
2Institute of Experimental Medicine, Gebze-Kocaeli, Türkiye

Keywords: Cas9, CRISPR-Cas9, CRISPR, gene, genome editing.


In the current era of science, many advancements are taking place. One of the most significant of these is clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), also known as genome editing technology, has become an exciting application in the scientific world, even earning the 2020 Nobel Prize in Chemistry. CRISPR-Cas9 serves as a genome editing tool, enabling researchers in the fields of Genetics and Medicine to add, remove, or modify deoxyribonucleic acid sequences. This technology finds applications in various fields, offering advantages such as greater speed, affordability, and higher accuracy compared to existing technologies. The purpose of this review is to offer insights into previous research on CRISPR-Cas9, a widely utilized technology across various scientific domains, with the aim of providing guidance for future studies.

Cite this article as: Demir Ö, Erbaş O. Discovery and applications of CRISPR-Cas9 gene editing technology. D J Tx Sci 2023;8(1-2):56-67. doi: 10.5606/ dsufnjt.2023.13.

Author Contributions

All authors contributed equally to the article.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.