Mine Ceren Akbulut, Oytun Erbaş

Institute of Experimental Medicine, Gebze-Kocaeli, Türkiye

Keywords: Decorin, IL-6, irisin, myokine, myonectin, myostatin.


Myokines are proteins that participate in various metabolic pathways released by skeletal muscle. They provide cross-talk between organs and muscles, induce muscle atrophy, improve muscle strength, induce muscle hypertrophy, induce glucose uptake, slow cancer progression, and reduce fat mass. Studies have examined the disease mechanisms that myokines may affect depending on the pathways they are involved in. In this review, myostatin, interleukin-6, interleukin-15, decorin, irisin, myonectin, and fibroblast growth factor 21 were examined as potential treatments. In addition, some concerns about myokines as therapeutics were listed.

Cite this article as: Ceren Akbulut M, Erbaş O. Possible therapeutics: Myokines. D J Tx Sci 2022;7(1-2):32-39.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions

All authors contributed equally to the article.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.