Yalda Sadeghian1, İlayda Üzümcü1, Oytun Erbaş2

1Institute of Experimental Medicine, Gebze-Kocaeli, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey

Keywords: Alpha-ketoglutarate, alpha-ketoglutarate dehydrogenase complex, cancer cells, cancer metabolism, epigenetics, hypoxia, tumor progression.


Uncontrolled and irregular metabolism is a characteristic of cancer cells. At the center of different metabolic pathways integrated into mitochondrial functions, the alpha (α)-ketoglutarate dehydrogenase complex is an important regulator of electron transport chain activity and tricarboxylic acid (TCA) cycle and a key enzyme for cancer cells. Different methods have been found in the fight against cancer, which is one of the greatest problems of our age. Alpha-ketoglutarate and α-ketoglutarate dehydrogenase have contributions to modulating the epigenetics of cancer cells. In this review, we will discuss the effects of the TCA cycle enzyme and its substrate on cancer, the development of cancer cells, and their orientation to other tissues.