Aslı Melike Ekmekçi1, Fehmi Balandi1, Oytun Erbaş2

1Institute of Experimental Medicine, Gebze-Kocaeli, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey

Keywords: Genetics, inflammation, obesity, RIPK1

Abstract

Obesity is a complex disease that affects women more than men, spreading like an avalanche in industrialized, developing, and underdeveloped countries. It is uncertain if inflammation is a cause or an effect in the pathophysiology of obesity-related increased body mass index. Obesity, inflammation, obesity genes, and genetic pathways that contribute to obesity-related inflammation are discussed in this review. The receptor-interacting serine/threonine-protein kinase 1 (RIPK1) gene was also highlighted in the role of genetics on obesity-related inflammation. In addition, studies on the importance of a genetic approach in obesity and the potential role of RIPK1 in inflammatory outcomes or cell death caused by obesity were included in this review. Although studies on the inflammatory consequences of obesity have gained attention recently, the literature on the links between obesity, inflammation, and RIPK1 is limited. Therefore, we believe that further research is needed to fully comprehend their mode of action.