Pakize Nur Akkaya

Department of Histology and Embryology, Balıkesir University Faculty of Medicine, Balıkesir, Turkey

Keywords: Ascorbic acid, sepsis, septic shock, steroid, thiamine, VICTAS


Sepsis is organ failure caused by an infection. It is one of the leading causes of in-hospital mortality worldwide. Standard treatment uses broad- spectrum antibiotics, fluid resuscitation, and vasopressor support in resistant hypotensive patients. Nevertheless, high morbidity and mortality rates in severe sepsis and septic shock have led to the search for new treatment modalities. In this review, we discuss the effects of intravenous ascorbic acid (vitamin C), thiamine (vitamin B1) and steroid treatment in addition to standard treatment in patients with severe sepsis and septic shock.

Conflict of Interest

The author declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The author received no financial support for the research and/or authorship of this article.