Ebru Sena Aslan1, Oytun Erbaş2

1Demiroğlu Bilim University Faculty of Medicine, Istanbul, Turkey
2Department of Physiology, Demiroğlu Bilim University Faculty of Medicine, Istanbul, Turkey

Keywords: Amyotrophic lateral sclerosis, lower motor neuron, spinal muscular atrophy, upper motor neuron.


Motor neurons are divided into upper motor neurons and lower motor neurons. Upper motor neurons transmit signals produced in the brain to the lower motor neurons. Lower motor neurons transmit these signals to the muscles of respective regions of the body to initiate motion. Injury to these motor neurons mainly result in motor neuron diseases, which may cause serious complications and death. This review discusses the definition, epidemiology, etiology, clinical symptoms, diagnosis, and treatment methods of the motor neuron diseases of amyotrophic lateral sclerosis and spinal muscular atrophy.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.