Dendritic cells and clinical applications in transplantation
Yonca Erdal1, Kubilay Doğan Kılıç2, Emel Öykü Çetin3, Yiğit Uyanıkgil2
1Ege Üniversitesi, Sağlık Bilimleri Enstitüsü, Kök Hücre Bölümü, İzmir, Türkiye
2Ege Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, İzmir, Türkiye
3Ege Üniversitesi Eczacılık Fakültesi, İlaç Teknolojisi, İzmir, Türkiye
Keywords: Applications; dendritic cells; dentritic cell vaccines; transplantation
Abstract
Dendritic cells are immunogenic and tolorogenic cells that present the first stage antigen in the immune system. Dendritic cells are usually found in peripheral tissues. Blood and skin are the most easily accessible structures to examine these cells. Dendritic cells are most commonly used in vaccine production and development. In this review we aim to examine the current status in dendritic cell vaccines and to investigate the progress of phase studies from a retrospective point of view.